Gruvberger et al. This is based on two observations derived from our gene expression profiling data in breast cancer [ 2 ]: the overlap between reporter genes for prognosis and ER status, and Gruvberger et al. We therefore believe that there is a different subset of genes that reports prognosis as compared with ER status.
Breast cancer patients with the same stage of disease can have markedly different treatment responses and overall outcome. The strongest predictors for metastases for example, lymph node status and histological grade fail to classify accurately breast tumours according to their clinical behaviour. None of the signatures of breast cancer gene expression reported to date allow for patient-tailored therapy strategies.
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An increasing number of breast cancer BC survivors are at risk of developing contralateral breast cancer CBC. We aimed to investigate the influence of various adjuvant systemic regimens on, subtype-specific, risk of CBC. This population-based cohort study included female patients diagnosed with first invasive BC between and ; follow-up was complete until
Gene expression regulators, such as transcription factors TFs and microRNAs miRNAshave varying regulatory targets based on the tissue and physiological state context within which they are expressed. While the emergence of regulator-characterizing experiments has inferred the target genes of many regulators across many contexts, methods for transferring regulator target genes across contexts are lacking. Further, regulator target gene lists frequently are not curated or have permissive inclusion criteria, impairing their use.