Trials to confirm these findings in healthy term infants, and in a non-West African setting, have not yet been carried out. In addition, a biological mechanism to explain such heterologous effects of BCG in the neonatal period has not been confirmed. This trial aims to address these issues by evaluating whether BCG non-specifically enhances the innate immune system in term Ugandan neonates, leading to increased protection from a variety of infectious diseases.
Pronounced: bah-sill-uhs kahl-met gey-rahn. Classification: Biologic Response Modifier. It works against cancer as a biologic response modifier.
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Intravesical therapy involves instillation of a therapeutic agent directly into the bladder via insertion of a urethral catheter. For administration of medication directly into bladder via catheterization utilizing sterile technique for interstitial cystitis flares, or non-muscle invasive bladder cancer treatment. This should include: associated health and safety issues regarding handling of cytotoxic, and immunotherapeutic agents; and documented competency of safe practical skills.
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Globally, BCG vaccination varies in efficacy and has some non-specific protective effects. Previous studies comparing BCG strains have been small-scale, with few or no immunological outcomes and have compared TB-specific responses only. We aimed to evaluate both specific and non-specific immune responses to different strains of BCG within a large infant cohort and to evaluate further the relationship between BCG strain, scarring and cytokine responses.
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BCG interviewed more than 17, people in 21 countries for the studyasking men and women to rank the importance of various obstacles for women at work. It found that the views of younger men — defined as those under age 40 — closely aligned with those of women of all ages. Younger men and women both placed a high importance on retaining employees, calling it the second-most important factor for a diverse workplace.